Tocopheryl Acetate Solubility. 9o (c 5, EtOH); see above. An oily solution of the synthetic dl -

9o (c 5, EtOH); see above. An oily solution of the synthetic dl -α-tocopheryl acetate was used containing 10 mg of dl -α-tocopheryl acetate of 10 IU of vitamin E (IU E)/gm of oil. α-Tocopheryl acetate is often used in dermatological products such as skin creams. . It is also soluble in alcohol but insolub. All eight stereoisomers have been synthesised. It protects the cells against free MONOGRAPH OF ALPHA-TOCOPHEROL Synonym Antisterility factor, alpha Tocopherol, fat soluble vitamin. Dec 16, 2024 · Vitamin E (INCI Tocopheryl Acetate) is a fat-soluble nutrient first identified through research on reproductive health. Dec 5, 2025 · Vitamin E Acetate is an active ingredient for use in cosmetic products for the skin and the hair. 5 mg/ml) in contrast to α-tocopherol, which is insoluble in water. Manufacture: Dl-alpha tocopheryl acetate is produced synthetically by the condensation of 2,3,5-trimethylhydroquinone with isophytol in an inert solvent (e. Due to these properties, there is a further problem that when ethyl acetate is employed in the preparation of α-tocopherol, byproduction of α-tocopheryl acetate is unavoidable. Buy Tocopheryl acetate. ChemicalBook provide Chemical industry users with Tocopheryl acetate Boiling point Melting point,Tocopheryl acetate Density MSDS Formula Use,If You also need to Tocopheryl acetate Other information,welcome to contact us. Water-soluble precursors of vitamin E (α-tocopherol, αT), such as its esters with acetate (αTA), succinate (αTS), or phosphate (αTP), have increased solubility in water and stability against reaction with free radicals, but they are rapidly converted during their uptake into the lipid-soluble vitamin E. Your institution may already be a subscriber. , Oxford University Press (New York, NY: 1986), p. ),Melting Point:-28°C,Boling Point:224°C0. Data for Biochemical Research, 3rd ed. However, in 1980, the term tocopherol equivalents (TE) was used to express the RDA for vitamin E. [Cohen et al. 6 days ago · It is insoluble in H2O but freely soluble in organic solvents. Nov 23, 2001 · The biological activity of 1 mg of dl-α-tocopheryl acetate, the synthesized form of vitamin E commonly used in food enrichment, is equivalent to 1 IU. Use:Used as a medicine, nutrition, cosmetics additives. Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. DL-a-TOCOPHEROL ACETATE For Biochemistry Confirming to Ph. Two reactions are associated with the protective mechanism of this molecule: tocopheryl radical generation under the influence of ROS and the singlet oxygen transformation into peroxide (Krieger-Liszkay and Trebst, 2006; Radyukina et al. such as sunflower This type of vitamin E is the type that is most active on our skin. Vitamin E Intakes and Status Tocopheryl acetate (vitamin E acetate) is a fat-soluble vitamin from a class of organic compounds, many of which are known to have vitamin E activity. Jul 1, 2008 · Caco-2 cells were used as a model for investigating and comparing the absorption of alpha-tocopherol (Tol) and alpha-tocopheryl acetate (Tac) solubili… Alpha-Tocopherol Vitamin E is the major lipid-soluble antioxidant that protects unsaturated fatty acid acyl chains in the cell membranes from oxidative damage. α-Tocopheryl acetate may be used as an internal standard in the determination of α-tocopherol in human serum or plasma samples using high performance chromatography (HPLC). The ring structure is identical to the α-tocopherol ring structure. Additionally, it is often used in skincare products due to its ability to improve skin texture, reduce the appearance of fine lines, and promote healthy-looking skin. 6 days ago · Tocopheryl Acetate (Vitamin E acetate) may be used as an analytical standard for the determination of the analyte in aquatic organisms, fish feed and pharmaceutical formulations by colorimetric and chromatography techniques, respectively. It is also found in dairy products, meat, eggs, cereals, nuts, and leafy green and yellow vegetables. 30041054 Articles Dl-alpha-tocopherol acetate | C31H52O3 | CID 2117 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological Dietary administration of (±)-α-tocopherol acetate (1,050 IU/kg) prevents sidestream cigarette smoke-induced decreases in body weight and lung dynamic compliance and increases in lung resistance in mice. Definition ChEBI: Alpha-Tocopherol acetate is a tocol. In contrast to vitamin E alcohol, vitamin E acetate is very stable against heat and oxygen. 138. Nov 8, 2022 · Vitamin E is a fat-soluble vitamin that plays several roles in your body, including serving as an antioxidant and boosting heart and eye health. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. Vitamin E Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties. Tocopheryl acetate (vitamin E acetate) is an antioxidant - naturally occurring chemicals that help prevent cell damage by fighting off highly reactive free radicals. Jun 18, 2025 · Common Generic Name (s): alpha-tocopherol, tocopherol, dl-alpha tocopheryl acetate, vitamin E Pronunciation: VYE-ta-min E Drug Classes: fat-soluble vitamin បើបានបងទិញឡេអាតូមីឲ្យលាប អូនឈប់កំព្រាហើយបងទៅណាទៅៗ藍 Atomy Body Lotion 4 days ago · Learn what to look for in tocopherol acetate powder, from purity and form to supplier reliability and usage needs. Furthermore, the product meets the specification of "all-rac-alpha-tocopheryl acetate" of FCC. Hansen Solubility Parameters for Tocopherol [59-02-9] and/or Tocopheryl Acetate [58-95-7] are needed. Here are the 10 best vitamin E supplements. NIST subscription sites provide data under the NIST Standard Reference Data Program, but require an annual fee to access. [4] [5] Vitamin E acetate, commonly referred to as Tocopherol acetate, appears as a clear, pale yellow to amber colored viscous liquid. alpha-Tocopherol succinate | C33H54O5 | CID 20353 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological Tocopheryl acetate is a chemical compound that is soluble in chloroform, ether, acetone, and vegetable oil. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). As an in-vivo antioxidant, it protects the cells against free radicals and prevents the peroxidation of body fats. Only one form, α-tocopherol, meets human vitamin E requirements (see The RDA). and "Vitamin E" of USP. Dietary administration of (±)-α-tocopherol acetate (1,050 IU/kg) prevents sidestream cigarette smoke-induced decreases in body weight and lung dynamic compliance and increases in lung resistance in mice. May solidify in the cold. Monice Zondlo Fiume, Final report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan; International Journal of Toxicology, (2002), 21(Suppl. Eur. Jul 31, 2017 · In this study, two stable forms of α-tocopherol, the hydrophobic acetate ester and the water-soluble phosphate ester, were tested in vitro as coating for titanium prosthesis. Stored at up to 25 °C, the product has a storage life of 36 months in the unopened original packaging. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0. , Dawson, R. Esters react with acids to liberate heat along with alcohols and acids. investigated the skin delivery of tocopherol acetate-loaded ELs [13]. and gives excellent results in neutralizing free radicals Protects skin cells from free radicals which are the cause of cell deter Alpha-tocopherol in dietary supplements and fortified foods is often esterified to prolong its shelf life while protecting its antioxidant properties. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. The product meets the specification of current monographs: "all-rac-alpha-tocopheryl acetate" of Ph. 74,Density:0. The body hydrolyzes and absorbs these esters (alpha-tocopheryl acetate and succinate) as efficiently as alpha-tocopherol [6]. Solubility: practically insoluble in water, freely soluble in acetone, in anhydrous ethanol, in methylene chloride and in fatty oils. Second identification: A, C. Vitamin E-Acetate SD 50 Chemical names of active ingredient all-rac- - tocopheryl acetate, DL-alpha-tocopheryl acetate, DL-alpha-tocopherol acetate, all-rac-alpha-tocopherol acetic acid ester, racemic 5,7,-trimethyltocol acetate CAS-No. M. Monice Zondlo Fiume, Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan; International Journal of Toxicology, (2002), 21(Suppl. It is vitamin E extracted from plants. It is unstable when exposed to alkalis (hydrolysis) and oxidants. It also tends to undergo a transesterification. -soluble; hence, vitamin E is known as a fat-soluble vitamin. Heat is also generated by the interaction of esters with caustic solutions. Recently, Caddeo et al. Alfa Chemistry offers D-Alpha-tocopheryl acetate (58-95-7) for experimental / research use. Shop Vitamin E Acetate Liquid 98% online for cosmetics, pharma & personal care. In two individuals with gastric carcinoma and lymphatic leukemia, the respective fractional absorption in the lymphatics was only 21 and 29 percent of label from meals containing alpha-tocopherol and alpha-tocopheryl acetate, respectively 4. The efficacy of tocopherol is, nevertheless, compromised by its chemical instability and poor aqueous solubility and this can be circumvented by formulating it into an appropriate delivery system [13]. Apr 4, 2014 · The Panel stated the following cosmetic ingredients should be included in this safety assessment: tocotrienols ascorbyl tocopheryl acetate ascorbyl tocopheryl maleate tocopheryl phosphate sodium tocopheryl phosphate Tocopheryl Acetate, also known as Vitamin E Acetate, is the stable form of Vitamin E, a naturally occurring antioxidant vitamin. Experimental data are the best but calculated values are also fit as nothing ones was found. Tocopheryl-phosphate (TP) has been used successfully as a vitamin E source around 1940 but it was subsequently α-Tocopherol acetate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques. 0 CHARACTERS Appearance: clear, colourless or yellowish-brown, viscous, oily liquid. Antimicrobial activity against microorganisms responsible of prosthetic and joints infections was assessed by broth microdilution method. We would like to show you a description here but the site won’t allow us. 3mm Hg (lit. Similar studies with Tocopheryl Acetate and Tocopheryl Succinate, however, demonstrated some enhancement of photocarcinogenesis, although the effect was not dose related. 1% ethanol. Determine the response factor (RF) for -tocopheryl acetate from the areas of the peak due to α-tocopheryl α acetate and the peak due to dotriacontane in the chromatogram obtained with the reference solution using the following expression: Alpha Tocopheryl Acetate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. The European Food Safety What's the difference between Tocopherol and Tocopheryl Acetate? Tocopherol and Tocopheryl Acetate are both forms of Vitamin E, but they have some key differ Further, ethyl acetate is extremely prone to hydrolysis under conditions other than neutral conditions, especially under basic conditions. benzene or hexane) with a catalyst such as zinc chloride. Alpha-tocopherol in dietary supplements and fortified foods is often esterified to prolong its shelf life while protecting its antioxidant properties. Jun 30, 2025 · Tocopheryl acetate is a stable, oil-soluble form of vitamin E created by combining natural tocopherol with acetic acid. Vitamin E Synthetic (DL-Alpha-Tocopheryl Acetate 50% 500 IU/g) Powder CWS is a water-soluble form of vitamin E, specifically formulated for use in food products and dietary supplements. 4% in swine and, therefore, is a poor vitamin E source. Created Date 11/2/2001 5:12:11 PM Visibly brightening, it helps protect the skin from harmful environmental aggressors like UV rays and pollution. Vitamin E is an important anti-oxidant which protects against lipid pe Structure What's the difference between Tocopherol and Tocopheryl Acetate? Tocopherol and Tocopheryl Acetate are both forms of Vitamin E, but they have some key differ The product complies with the acceptance criteria specified in the current individual monographs for "all-rac-alpha-tocopheryl acetate" of Ph. Up until 1980, the recommended daily allowance (RDA) for vitamin E was expressed in IU. - Vitamin E (tocopheryl acetate and tocopherol): a blend of fat-soluble antioxidants that help neutralize free radicals to combat damage caused by environmental aggressors. C. Store at 2-8°C Vitamin E acetate; all-rac-a-Tocopheryl acetate Dl-alpha-tocopherol acetate | C31H52O3 | CID 2117 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological Tocopheryl acetate is a form of vitamin E, an antioxidant, what can help fight free radical damage and promote skin healing to diminish signs of aging. You can also browse global suppliers,vendor,prices,Price,manufacturers of Tocopheryl acetate (7695-91-2). , et al. It is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol. An ester. 6 days ago · D-alpha-Tocopheryl acetate (CAS 58-95-7) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook. Alpha-Tocopherol acetate is a tocol. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169. Name:Vitamin E Acetate,CAS:7695-91-2. It also may provide strength to the protective barrier of the skin to prevent moisture loss. Solutions of this product remain active at 2–8 °C for several months. Solubility: Freely soluble in absolute ethanol, acetone, chloroform, ether and fixed oils, soluble in ethanol (96%); slightly soluble in alcohol; practically insoluble in water Regulations Quality Documentation). View information & documentation regarding D-Alpha-tocopheryl acetate, including CAS, structure & more. The resulting alpha tocopherol is then treated with acetic anhydride to give tocopheryl acetate. 30041054 | Vitamin E-Acetate | Technical Information Animal NutritionPage 1 of 2 Active ingredient Vitamin E acetate (dl-alpha-tocopheryl acetate) PRD-No. Comment on solubility Solubility of [2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)chroman-6-yl] acetate The solubility of the compound [2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)chroman-6-yl] acetate, with the molecular formula C 31 H 52 O 3, exhibits some interesting characteristics primarily due to its large organic structure. Vitamin E Intakes and Status ChemicalBook provide Chemical industry users with Tocopheryl acetate Boiling point Melting point,Tocopheryl acetate Density MSDS Formula Use,If You also need to Tocopheryl acetate Other information,welcome to contact us. Dec 10, 2015 · Pharmacodynamics In addition to any following information, owing to d-alpha-Tocopherol acetate's closely related chemical nature with alpha-Tocopherol acetate, please also refer to the drug information page for alpha-Tocopherol acetate for further data. , "Vitamin E" of USP, "Tocopheryl-Acetate" of IP, "Tocopherol acetate" of JP (english version), "all-rac-alpha-Tocopheryl Acetate" of Japan`s Specifications and Standards for Food Additives and "Vitamin E" Nov 3, 2025 · Tocopheryl acetate is a specific derivative of vitamin E acetic ester of all-racemic alpha-tocopherol, belonging to the group of oil-soluble Vitamins in a class of organic chemicals known as tocopherols. ),Flashing Point:>230°F,Solubility:Immiscible with water. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Eur, USP. Subsequent research isolated Vitamin E from wheat germ oil and determined its chemical structure, uncovering its various forms, including tocopherols and tocotrienols. IDENTIFICATION First identification: A, B. 2 per cent of the area of the peak due to all-rac- -tocopheryl acetate. g. Premium Alpha Tocopheryl Acetate with quick shipping. Most commercial tocopherol is extracted from vegetable oils such as soybean, sunflower or wheat germ, then purified and esterified to become tocopheryl acetate. Visit ChemicalBook To find more Tocopheryl acetate (7695-91-2) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. And free radicals. Sodium Ascorbyl Phosphate is water soluble and can be used as such in this aqueous cell system. Being a strong antioxidant, tocopherol is unstable and is usually esterified to facilitate stability; tocopheryl acetate is the most widely used form. This strong antioxidant has some water solubility (0. ChemSpider record containing structure, synonyms, properties, vendors and database links for Tocopheryl acetate, 58-95-7, Evion, ZAKOWWREFLAJOT-CEFNRUSXSA-N Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. , "Vitamin E" of USP, "Tocopheryl-Acetate" of IP, "Tocopherol acetate" of JP (english version), "all-rac-alpha-Tocopheryl Acetate" of Japan`s Specifications and Standards for Food Additives and "Vitamin E" Jun 26, 2025 · Tocopheryl acetate is a form of vitamin E that’s often found in skin care products and dietary supplements. , 2019). 7mm and [] D 20 +3. RRR-α-Tocopheryl acetate — in the chromatogram obtained with reference solution (a), the area of the peak due to impurity C is not greater than 0. In clinical studies, Tocopherol, Tocopheryl Acetate, and Tocopheryl Nicotinate were not irritants or sensitizers. Solutions should be protected from light. It is commonly used in skin care, hair care, and cosmetic products for its moisturizing and skin-soothing properties. Tocopheryl acetate is a form of vitamin E, a natural skin-conditioning agent and antioxidant. To keep the conditions as simple as possible, ethanol was used as vehicle. Regulations Quality Documentation). 3), 51-116. Apr 5, 2023 · Tocopheryl Acetate is known for its antioxidant properties which help protect the skin from environmental stressors such as pollution and UV radiation. Vitamin E is defined as α-tocopherol, while tocochromanols describes a family of eight fat-soluble molecules with antioxidant activities: four tocopherol isoforms (α-, β-, γ-, and δ-tocopherol) and four tocotrienol isoforms (α-, β-, γ-, and δ-tocotrienol) (Figure 1). Vitamin E has antioxidant activity. Vitamin E Acetate was dissolved in 0. Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate and Dioleyl Tocopheryl Methylsilanol also function as skin-conditioning agents – miscellaneous. 96 g/mL at 20 °C (lit. Molecular Fomula:C31H52O3,Molar Mass:472. Tocopheryl acetate is a fat-soluble vitamin that can be isolated from vegetable oils. This mix of stereoisomers is often called dl -α-tocopheryl acetate. 42E-09mmHg at 25°C ChemSpider record containing structure, synonyms, properties, vendors and database links for α-Tocopheryl acetate, ZAKOWWREFLAJOT-BVXAZASISA-N Jan 10, 2026 · Material Safety Data Sheet or SDS for Tocopheryl acetate 7695-91-2 from chemicalbook for download or viewing in the browser CAS # : 7695-91-2 Synonym: Vitamin E acetate; DL-a-Tocopheryl acetate Physical Appearance: Clear, slightly greenish-yellow, viscous oily liquid. Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It is added as alpha-tocopherol to ILE with high PUFA content to prevent peroxidation. Alpha-tocopherol, either naturally extracted from plant oils or, most commonly, as the synthetic tocopheryl acetate, is sold as a popular dietary supplement, either by itself or incorporated into a multivitamin product, and in oils or lotions for use on skin. This synthetic tocopherol variant provides a stable source of vitamin E, an essential nutrient known for its antioxidant properties, which help to protect cells from oxidative stress. ,Vapor Presure:1. The fat-soluble nature of tocopherol plays a key role in defense from membrane lipid peroxidation. It is known for its stability and lack of odor, making it a favorable choice in the formulation of skincare and cosmetic products. In 1956, the distribution of these samples was suspended, because synthetic dl -α-tocopheryl acetate in pure form has become easily available. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. ] EUROPEAN PHARMACOPOEIA 7. Vitamin E Acetate is insoluble in water and has to be brought into solution with a vehicle. General Description SAFETY DATA SHEET VITAMIN E ACETATE 98% PRODUCT INFORMATION AND COMPANY IDENTIFICATION Tocopheryl acetate is the acetate ester of tocopherol (vitamin E). These micelles have proven to be very efective, non-toxic, biocompatible, and biodegradable nanocarriers for the delivery of a poorly soluble vitamin E analogue, α-tocopheryl acetate, to sows and piglets. ChemicalBook provide information on the 7695-91-2: structure, uses, msds, molecular formula, cas, and suppliers. Also, for use with USP monographs such as: Vitamin E Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties. α-tocopheryl acetate, an acetate ester of α-tocopherol Manufacturers also commonly convert the phenol form of the vitamins (with a free hydroxyl group) to esters, using acetic or succinic acid. In the human liver, α-tocopherol is . The purpose of the fee is to recover costs associated with the development of data collections included in such sites. Learn about its potential benefits and risks. Vitamin E, as all-rac α-tocopheryl-acetate (TAc), has a bioavailability of only 5. [12] Starting with May 2016, the IU unit is made obsolete, such that 1 mg of "Vitamin E" is 1 mg of d-alpha-tocopherol or 2 mg of dl-alpha-tocopherol. , This compound is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits.

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